Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells

Little is known about the regulation of the oncomiR miR-21 in liver. Dehydroepiandrosterone (DHEA) regulates gene expression as a ligand for a G-protein-coupled receptor and as a precursor for steroids that activate nuclear receptor signaling. We report that 10 nm DHEA increases primary miR-21 (pri-...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Teng, Yun, Radde, Brandie N., Litchfield, Lacey M., Ivanova, Margarita M., Prough, Russell A., Clark, Barbara J., Doll, Mark A., Hein, David W., Klinge, Carolyn M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505488/
https://ncbi.nlm.nih.gov/pubmed/25969534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641167
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