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Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor

Although oncomiR miR-21 is highly expressed in liver and overexpressed in hepatocellular carcinoma (HCC), its regulation is uncharacterized. We examined the effect of physiologically relevant nanomolar concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) on miR-21 expression in...

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Main Authors: Teng, Yun, Litchfield, Lacey M., Ivanova, Margarita M., Prough, Russell A., Clark, Barbara J., Klinge, Carolyn M.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074919/
https://ncbi.nlm.nih.gov/pubmed/24845419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2014.05.007
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