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Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins
Interchanging Leu-119 for Pro-119 at the tip of the β(4)-β(5) loop in the first FK506 binding domain (FK1) of the FKBP51 and FKBP52 proteins, respectively, has been reported to largely reverse the inhibitory (FKBP51) or stimulatory (FKBP52) effects of these co-chaperones on the transcriptional activ...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505484/ https://ncbi.nlm.nih.gov/pubmed/25953903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650655 |
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