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The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage

The non-receptor tyrosine kinase c-Abl is activated in response to DNA damage and induces p73-dependent apoptosis. Here, we investigated c-Abl regulation of the homeodomain-interacting protein kinase 2 (HIPK2), an important regulator of p53-dependent apoptosis. c-Abl phosphorylated HIPK2 at several...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Reuven, Nina, Adler, Julia, Porat, Ziv, Polonio-Vallon, Tilman, Hofmann, Thomas G., Shaul, Yosef
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505402/
https://ncbi.nlm.nih.gov/pubmed/25944899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.628982
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