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The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl

The Hippo pathway is an evolutionarily conserved pathway that controls cell proliferation, organ size, tissue regeneration and stem cell self-renewal. Here we show that it also regulates the DNA damage response. At high cell density, when the Hippo pathway is active, DNA damage-induced apoptosis and...

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Hlavní autoři: Reuven, N, Adler, J, Meltser, V, Shaul, Y
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770326/
https://ncbi.nlm.nih.gov/pubmed/23852372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.83
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