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Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

Non-receptor tyrosine kinase Src is a master regulator of cell proliferation. Hyperactive Src is a potent oncogene and a driver of cellular transformation and carcinogenesis. Homeodomain-interacting protein kinase 2 (HIPK2) is a tumor suppressor mediating growth suppression and apoptosis upon genoto...

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Detalhes bibliográficos
Main Authors: Polonio-Vallon, Tilman, Kirkpatrick, Joanna, Krijgsveld, Jeroen, Hofmann, Thomas G
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925721/
https://ncbi.nlm.nih.gov/pubmed/24196445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26857
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