Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin

Among the four groups of HIV-1 (M, N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract huma...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Iwami, Shingo, Sato, Kei, Morita, Satoru, Inaba, Hisashi, Kobayashi, Tomoko, Takeuchi, Junko S., Kimura, Yuichi, Misawa, Naoko, Ren, Fengrong, Iwasa, Yoh, Aihara, Kazuyuki, Koyanagi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505337/
https://ncbi.nlm.nih.gov/pubmed/26184634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12256
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