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Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

Junctophilin-2 (JP2), a membrane-binding protein that provides a structural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise Ca(2+)-induced Ca(2+) release during excitation-contraction coupling in cardiomyocytes. In animal and human failing hearts, expression of JP...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Guo, Ang, Hall, Duane, Zhang, Caimei, Peng, Tianqing, Miller, Jordan D., Kutschke, William, Grueter, Chad E., Johnson, Frances L., Lin, Richard Z., Song, Long-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505042/
https://ncbi.nlm.nih.gov/pubmed/26063807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652396
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