Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist

RATIONALE: Previous reports shows rimonabant's inverse properties may be a limiting factor for treating cannabinoid dependence. To overcome this limitation neutral antagonists were developed, to address mechanisms by which an inverse agonist and neutral antagonist elicit withdrawal. OBJECTIVE:...

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Pubblicato in:Psychopharmacology (Berl)
Autori principali: Tai, Sherrica, Nikas, Spyros P., Shukla, Vidyanand G., Vemuri, Kiran, Makriyannis, Alexandros, Järbe, Torbjörn U.C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504748/
https://ncbi.nlm.nih.gov/pubmed/25772338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-3907-0
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