Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S., Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T., Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504485/
https://ncbi.nlm.nih.gov/pubmed/26181660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005011
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker