Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S., Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T., Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504485/
https://ncbi.nlm.nih.gov/pubmed/26181660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005011
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