Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

Mycolactone is a diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show that mycolactone operates by hijacking the Wiskott-Aldrich syndrome protein (WASP) family of actin-nucleating factors....

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Detalhes bibliográficos
Main Authors: Guenin-Macé, Laure, Veyron-Churlet, Romain, Thoulouze, Maria-Isabel, Romet-Lemonne, Guillaume, Hong, Hui, Leadlay, Peter F., Danckaert, Anne, Ruf, Marie-Thérèse, Mostowy, Serge, Zurzolo, Chiara, Bousso, Philippe, Chrétien, Fabrice, Carlier, Marie-France, Demangel, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613928/
https://ncbi.nlm.nih.gov/pubmed/23549080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66576
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