Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

Mycolactone is a diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show that mycolactone operates by hijacking the Wiskott-Aldrich syndrome protein (WASP) family of actin-nucleating factors....

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Autores principales: Guenin-Macé, Laure, Veyron-Churlet, Romain, Thoulouze, Maria-Isabel, Romet-Lemonne, Guillaume, Hong, Hui, Leadlay, Peter F., Danckaert, Anne, Ruf, Marie-Thérèse, Mostowy, Serge, Zurzolo, Chiara, Bousso, Philippe, Chrétien, Fabrice, Carlier, Marie-France, Demangel, Caroline
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613928/
https://ncbi.nlm.nih.gov/pubmed/23549080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66576
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