Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

INTRODUCTION: Interleukin (IL)-21 is a key cytokine in autoimmune diseases such as systemic lupus erythematosus (SLE) by its regulation of autoantibody production and inflammatory responses. The objective of this study is to investigate the signaling capacity of IL-21 in T and B cells and assess its...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Rasmussen, Tue Kruse, Andersen, Thomas, Bak, Rasmus Otkjær, Yiu, Gloria, Sørensen, Christian Møller, Stengaard-Pedersen, Kristian, Mikkelsen, Jacob Giehm, Utz, Paul Joseph, Holm, Christian Kanstrup, Deleuran, Bent
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504038/
https://ncbi.nlm.nih.gov/pubmed/26055806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0660-z
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