Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

Protein arginylation is an emerging post-translational modification that targets a number of metabolic enzymes, however the mechanisms and downstream effects of this modification are unknown. Here we show that lack of arginylation renders cells vulnerable to purine nucleotide synthesis inhibitors an...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zhang, Fangliang, Patel, Devang M., Colavita, Kristen, Rodionova, Irina, Buckley, Brian, Scott, David, Kumar, Akhilesh, Shabalina, Svetlana A., Saha, Sougata, Chernov, Mikhail, Osterman, Andrei, Kashina, Anna
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503932/
https://ncbi.nlm.nih.gov/pubmed/26175007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8517
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