Individual and combined associations of genetic variants in CYP3A4, CYP3A5, and SLCO1B1 with simvastatin and simvastatin acid plasma concentrations

Our objective was to evaluate the associations of genetic variants affecting simvastatin (SV) and simvastatin acid (SVA) metabolism (CYP3A4*22 and CYP3A5*3) and transport (SLCO1B1 T521C) with 12-hour plasma SV and SVA concentrations. The variants were genotyped, and concentrations were quantified by...

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Foilsithe in:J Cardiovasc Pharmacol
Main Authors: Luzum, Jasmine A., Theusch, Elizabeth, Taylor, Kent D., Wang, Ann, Sadee, Wolfgang, Binkley, Philip F., Krauss, Ronald M., Medina, Marisa W., Kitzmiller, Joseph P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503374/
https://ncbi.nlm.nih.gov/pubmed/26164721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000246
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