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Interactions Between Regulatory Variants in CYP7A1 Promoter and Enhancer Regions Regulate CYP7A1 Expression
BACKGROUND: Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the rate-limiting step in bile acid biosynthesis from cholesterol, a main pathway for cholesterol removal from the body. CYP7A1 SNPs are associated with total cholesterol and LDL levels, risk of cardiovascular diseases, and other phenotypes;...
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| Publicado no: | Circ Genom Precis Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6211808/ https://ncbi.nlm.nih.gov/pubmed/30354296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.118.002082 |
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