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Regulatory polymorphisms in CYP2C19 affecting hepatic expression
BACKGROUND: Cytochrome P450 2C19 is responsible for the metabolism of many drugs, including the activation of clopidogrel. The allele CYP2C19*17 is associated with ultra-rapid metabolizer phenotypes by increasing gene transcription. This study tests to what extent CYP2C19*17 enhances CYP2C19 express...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755489/ https://ncbi.nlm.nih.gov/pubmed/23412869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/dmdi-2012-0038 |
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