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Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production

The autoimmune disease systemic lupus erythematosus (SLE) has a complex environmental and multi-factorial genetic basis. Genome wide association studies have recently identified numerous disease-associated polymorphisms, but it remains unclear in which cells and during which step of pathogenesis spe...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Mills, Robyn E., Lam, Viola C., Tan, Allison, Cresalia, Nicole, Oksenberg, Nir, Zikherman, Julie, Anderson, Mark, Weiss, Arthur, Hermiston, Michelle L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503364/
https://ncbi.nlm.nih.gov/pubmed/25769918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500026
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