Pore-Exposed Tyrosine Residues of P-Glycoprotein Are Important Hydrogen-Bonding Partners for Drugs()

The multispecific efflux transporter, P-glycoprotein, plays an important role in drug disposition. Substrate translocation occurs along the interface of its transmembrane domains. The rotational C2 symmetry of ATP-binding cassette transporters implies the existence of two symmetry-related sets of su...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Cakil, Yaprak Dönmez, Khunweeraphong, Narakorn, Parveen, Zahida, Schmid, Diethart, Artaker, Matthias, Ecker, Gerhard F., Sitte, Harald H., Pusch, Oliver, Stockner, Thomas, Chiba, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503343/
https://ncbi.nlm.nih.gov/pubmed/24366667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088526
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki