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Molecular Dissection of Dual Pseudosymmetric Solute Translocation Pathways in Human P-Glycoprotein
The human multispecific drug efflux transporter P-glycoprotein (P-gp) causes drug resistance and modulates the pharmacological profile of systemically administered medicines. It has arisen from a homodimeric ancestor by gene duplication. Crystal structures of mouse MDR1A indicate that P-gp shares th...
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| Vydáno v: | Mol Pharmacol |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422312/ https://ncbi.nlm.nih.gov/pubmed/21177413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067611 |
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