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On the mechanism of iron sensing by IRP2: new players, new paradigms
Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin l...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4503334/ https://ncbi.nlm.nih.gov/pubmed/26190951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.261 |
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