Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus

BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We inve...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hafrén, Lena, Einarsdottir, Elisabet, Kentala, Erna, Hammarén-Malmi, Sari, Bhutta, Mahmood F., MacArthur, Carol J., Wilmot, Beth, Casselbrant, Margaretha, Conley, Yvette P., Weeks, Daniel E., Mandel, Ellen M., Vaarala, Outi, Kallio, Anna, Melin, Merit, Nieminen, Janne K., Leinonen, Eira, Kere, Juha, Mattila, Petri S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503307/
https://ncbi.nlm.nih.gov/pubmed/26177520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132551
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