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On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

TRAIL and agonistic antibodies against TRAIL death receptors kill tumor cells while causing virtually no damage to normal cells. Several novel drugs targeting TRAIL receptors are currently in clinical trials. However, TRAIL resistance is a common obstacle in TRAIL based therapy and limits the effici...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Dimberg, Lina Y., Anderson, Charles K., Camidge, Ross, Behbakht, Kian, Thorburn, Andrew, Ford, Heide L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502956/
https://ncbi.nlm.nih.gov/pubmed/22580613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.164
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