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A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1

The discovery that heterozygous disruption of Becn1 in mice leads to spontaneous tumor development was the first direct link arguing for a predominantly tumor-suppressor function of autophagy. However, the mechanisms by which BECN1 restrains tumorigenesis and whether autophagy-independent functions...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Elgendy, Mohamed, Minucci, Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502650/
https://ncbi.nlm.nih.gov/pubmed/25837021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1029836
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