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A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1
The discovery that heterozygous disruption of Becn1 in mice leads to spontaneous tumor development was the first direct link arguing for a predominantly tumor-suppressor function of autophagy. However, the mechanisms by which BECN1 restrains tumorigenesis and whether autophagy-independent functions...
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| 發表在: | Autophagy |
|---|---|
| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4502650/ https://ncbi.nlm.nih.gov/pubmed/25837021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1029836 |
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