Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

BACKGROUND: The clusterin (CLU) gene has been identified as an important risk locus for Alzheimer’s disease (AD). Although the actual risk–increasing polymorphisms at this locus remain to be identified, we previously observed an increased frequency of rare non-synonymous mutations and small insertio...

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Bibliografski detalji
Izdano u:Mol Neurodegener
Glavni autori: Bettens, Karolien, Vermeulen, Steven, Van Cauwenberghe, Caroline, Heeman, Bavo, Asselbergh, Bob, Robberecht, Caroline, Engelborghs, Sebastiaan, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Deyn, Peter Paul, Cruts, Marc, Van Broeckhoven, Christine, Sleegers, Kristel
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502563/
https://ncbi.nlm.nih.gov/pubmed/26179372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0024-9
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