Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

BACKGROUND: The clusterin (CLU) gene has been identified as an important risk locus for Alzheimer’s disease (AD). Although the actual risk–increasing polymorphisms at this locus remain to be identified, we previously observed an increased frequency of rare non-synonymous mutations and small insertio...

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Publicat a:Mol Neurodegener
Autors principals: Bettens, Karolien, Vermeulen, Steven, Van Cauwenberghe, Caroline, Heeman, Bavo, Asselbergh, Bob, Robberecht, Caroline, Engelborghs, Sebastiaan, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Deyn, Peter Paul, Cruts, Marc, Van Broeckhoven, Christine, Sleegers, Kristel
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502563/
https://ncbi.nlm.nih.gov/pubmed/26179372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0024-9
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