Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

BACKGROUND: We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an extended Flanders-Belgian cohort of Caucasian AD patient...

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Detalhes bibliográficos
Main Authors: Bettens, Karolien, Brouwers, Nathalie, Engelborghs, Sebastiaan, Lambert, Jean-Charles, Rogaeva, Ekaterina, Vandenberghe, Rik, Le Bastard, Nathalie, Pasquier, Florence, Vermeulen, Steven, Van Dongen, Jasper, Mattheijssens, Maria, Peeters, Karin, Mayeux, Richard, St George-Hyslop, Peter, Amouyel, Philippe, De Deyn, Peter P, Sleegers, Kristel, Van Broeckhoven, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296573/
https://ncbi.nlm.nih.gov/pubmed/22248099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-3
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