Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

BACKGROUND: We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an extended Flanders-Belgian cohort of Caucasian AD patient...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bettens, Karolien, Brouwers, Nathalie, Engelborghs, Sebastiaan, Lambert, Jean-Charles, Rogaeva, Ekaterina, Vandenberghe, Rik, Le Bastard, Nathalie, Pasquier, Florence, Vermeulen, Steven, Van Dongen, Jasper, Mattheijssens, Maria, Peeters, Karin, Mayeux, Richard, St George-Hyslop, Peter, Amouyel, Philippe, De Deyn, Peter P, Sleegers, Kristel, Van Broeckhoven, Christine
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296573/
https://ncbi.nlm.nih.gov/pubmed/22248099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi