Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium

Anoctamin 1 (ANO1)/TMEM16A is a Cl(−) channel activated by intracellular Ca(2+) mediating numerous physiological functions. However, little is known of the ANO1 activation mechanism by Ca(2+). Here, we demonstrate that two helices, “reference” and “Ca(2+) sensor” helices in the third intracellular l...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Lee, Jesun, Jung, Jooyoung, Tak, Min Ho, Wee, Jungwon, Lee, Byeongjoon, Jang, Yongwoo, Chun, Hyeyeon, Yang, Dong-Jin, Yang, Young Duk, Park, Sang Ho, Han, Byung Woo, Hyun, Soonsil, Yu, Jaehoon, Cho, Hawon, Hartzell, H. Criss, Oh, Uhtaek
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Ion Channels, Receptors and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502317/
https://ncbi.nlm.nih.gov/pubmed/25231974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-014-1603-2
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