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Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium
Anoctamin 1 (ANO1)/TMEM16A is a Cl(−) channel activated by intracellular Ca(2+) mediating numerous physiological functions. However, little is known of the ANO1 activation mechanism by Ca(2+). Here, we demonstrate that two helices, “reference” and “Ca(2+) sensor” helices in the third intracellular l...
Shranjeno v:
| izdano v: | Pflugers Arch |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Berlin Heidelberg
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4502317/ https://ncbi.nlm.nih.gov/pubmed/25231974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-014-1603-2 |
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