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Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.

This work analyzes the action of enacyloxin Ila, an inhibitor of bacterial protein biosynthesis. Enacyloxin IIa [IC50 on poly(Phe) synthesis approximately 70 nM] is shown to affect the interaction between elongation factor (EF) Tu and GTP or GDP; in particular, the dissociation of EF-Tu-GTP is stron...

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Bibliographic Details
Main Authors: Cetin, R, Krab, I M, Anborgh, P H, Cool, R H, Watanabe, T, Sugiyama, T, Izaki, K, Parmeggiani, A
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC450193/
https://ncbi.nlm.nih.gov/pubmed/8665868
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