Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation that has been proposed to have a key role in regulating the response to mechanical loading. To investigate the effect of long-term Sclerostin deficiency on mechanotransduction in bone, we performed experiments...

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Bibliografiska uppgifter
I publikationen:J Bone Miner Res
Huvudupphovsmän: Morse, Alyson, McDonald, Michelle Maree, Kelly, Natalie H, Melville, Katherine M, Schindeler, Aaron, Kramer, Ina, Kneissel, Michaela, van der Meulen, Marjolein CH, Little, David Graham
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501925/
https://ncbi.nlm.nih.gov/pubmed/24821585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2278
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