Mechanisms of Activation of Nucleus Accumbens Neurons by Cocaine via Sigma-1 Receptor - Inositol 1,4,5-Trisphosphate - Transient Receptor Potential Canonical Channel Pathways

Cocaine promotes addictive behavior primarily by blocking the dopamine transporter, thus increasing dopamine transmission in the nucleus accumbens (nAcc); however, additional mechanisms are continually emerging. Sigma-1 receptors (σ(1)Rs) are known targets for cocaine, yet the mechanisms underlying...

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Publicado en:Cell Calcium
Autores principales: Barr, Jeffrey L., Deliu, Elena, Brailoiu, G. Cristina, Zhao, Pingwei, Yan, Guang, Abood, Mary E., Unterwald, Ellen M., Brailoiu, Eugen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501893/
https://ncbi.nlm.nih.gov/pubmed/26077147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2015.05.001
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