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Cocaine Inhibits Store-Operated Ca(2+) Entry in Brain Microvascular Endothelial Cells: Critical Role for Sigma-1 Receptors

Sigma-1 receptor (Sig-1R) is an intracellular chaperone protein with many ligands, located at the endoplasmic reticulum. Binding of cocaine to Sig-1R has previously been found to modulate endothelial functions. In the present study, we show that cocaine dramatically inhibits store-operated Ca(2+) en...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Brailoiu, G. Cristina, Deliu, Elena, Console-Bram, Linda M, Soboloff, Jonathan, Abood, Mary E, Unterwald, Ellen M, Brailoiu, Eugen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679692/
https://ncbi.nlm.nih.gov/pubmed/26467159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150934
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