An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif.

HOX homeoproteins control cell identities during animal development by differentially regulating target genes. The homeoprotein encoded by the extradenticle (exd) gene can selectively modify HOX DNA binding, suggesting that it contributes to HOX specificity in vivo. HOX-EXD interactions are in part...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chan, S K, Pöpperl, H, Krumlauf, R, Mann, R S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1996
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC450180/
https://ncbi.nlm.nih.gov/pubmed/8665855
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