An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif.

HOX homeoproteins control cell identities during animal development by differentially regulating target genes. The homeoprotein encoded by the extradenticle (exd) gene can selectively modify HOX DNA binding, suggesting that it contributes to HOX specificity in vivo. HOX-EXD interactions are in part...

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書目詳細資料

發表在:	EMBO J
Principais autores:	Chan, S K, Pöpperl, H, Krumlauf, R, Mann, R S
格式:	Artigo
語言:	Inglês
出版:	Nature Publishing Group 1996
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450180/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665855/
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