NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5

We previously observed that glioma cells are differentially sensitive to TRAIL-induced toxicity. Based on our observation that TRAIL-resistant glioma cell lines typically exhibited high levels of Akt activation, we hypothesized that inhibition of Akt signaling using the PI3 kinase inhibitor NVP-BKM1...

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Vydáno v:Int J Oncol
Hlavní autoři: FOSTER, KIMBERLY A., JANE, ESTHER P., PREMKUMAR, DANIEL R., MORALES, ALEJANDRO, POLLACK, IAN F.
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2015
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501659/
https://ncbi.nlm.nih.gov/pubmed/26044191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.3035
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