Inhibition of Phosphatidylinositol 3-Kinase/AKT Signaling by NVP-BKM120 Promotes ABT-737–Induced Toxicity in a Caspase-Dependent Manner through Mitochondrial Dysfunction and DNA Damage Response in Established and Primary Cultured Glioblastoma Cells

Identification of therapeutic strategies that might enhance the efficacy of B-cell lymphoma-2 (Bcl-2) inhibitor ABT-737 [N-{4-[4-(4-chloro-biphenyl-2-ylmethyl)-piperazin-1-yl]-benzoyl}-4-(3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-nitro-benzenesulfonamide] is of great interest in many can...

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Detalles Bibliográficos
Autores principales: Jane, Esther P., Premkumar, Daniel R., Morales, Alejandro, Foster, Kimberly A., Pollack, Ian F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
Materias:
Cellular and Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056270/
https://ncbi.nlm.nih.gov/pubmed/24741074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.212910
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