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Regulation of expression of O(6)-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)
O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O(6)-methylguanine (O(6)-MG) DNA residue, thus correcting the mismatches of O(6)-MG with a thymine residue during DNA replication. The dealkylating effect of MGMT is relevant not only in repairing...
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| Pubblicato in: | Int J Oncol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
D.A. Spandidos
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501657/ https://ncbi.nlm.nih.gov/pubmed/26035292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.3026 |
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