Rifampicin-Independent Interactions between the Pregnane X Receptor Ligand Binding Domain and Peptide Fragments of Coactivator and Corepressor Proteins

[Image: see text] The pregnane X receptor (PXR), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolizing enzymes in a ligand-dependent manner. The conventional view of nuclear receptor action is that ligand binding enhances the receptor’s affinity for coactivator...

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Publié dans:Biochemistry
Auteurs principaux: Navaratnarajah, Punya, Steele, Bridgett L., Redinbo, Matthew R., Thompson, Nancy L.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501269/
https://ncbi.nlm.nih.gov/pubmed/22185585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2011674
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