Intracellular Crotonyl-CoA Stimulates Transcription Through p300-Catalyzed Histone Crotonylation

Acetylation of histones at DNA regulatory elements plays a critical role in transcriptional activation. Histones are also modified by other acyl moieties, including crotonyl, yet the mechanisms that govern acetylation versus crotonylation and the functional consequences of this “choice” remain uncle...

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Pubblicato in:Mol Cell
Autori principali: Sabari, Benjamin R., Tang, Zhanyun, Huang, He, Yong-Gonzalez, Vladimir, Molina, Henrik, Kong, Ha Eun, Dai, Lunzhi, Shimada, Miho, Cross, Justin R., Zhao, Yingming, Roeder, Robert G., Allis, C. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501262/
https://ncbi.nlm.nih.gov/pubmed/25818647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.029
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