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Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

Targeted disruption of the insulin receptor gene (Insr) in the mouse was achieved using the homologous recombination approach. Insr+/- mice were normal as shown by glucose tolerance tests. Normal Insr-/- pups were born at expected rates, indicating that Insr can be dispensable for intrauterine devel...

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Détails bibliographiques
Auteurs principaux: Joshi, R L, Lamothe, B, Cordonnier, N, Mesbah, K, Monthioux, E, Jami, J, Bucchini, D
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC450062/
https://ncbi.nlm.nih.gov/pubmed/8612577
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