Phenotypic alterations in insulin-deficient mutant mice

Two mouse insulin genes, Ins1 and Ins2, were disrupted and lacZ was inserted at the Ins2 locus by gene targeting. Double nullizygous insulin-deficient pups were growth-retarded. They did not show any glycosuria at birth but soon after suckling developed diabetes mellitus with ketoacidosis and liver...

詳細記述

書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Duvillié, Bertrand, Cordonnier, Nathalie, Deltour, Louise, Dandoy-Dron, Françoise, Itier, Jean-Michel, Monthioux, Eliane, Jami, Jacques, Joshi, Rajiv L., Bucchini, Danielle
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1997
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24644/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144203/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5137
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!