Phenotypic alterations in insulin-deficient mutant mice

Two mouse insulin genes, Ins1 and Ins2, were disrupted and lacZ was inserted at the Ins2 locus by gene targeting. Double nullizygous insulin-deficient pups were growth-retarded. They did not show any glycosuria at birth but soon after suckling developed diabetes mellitus with ketoacidosis and liver...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Duvillié, Bertrand, Cordonnier, Nathalie, Deltour, Louise, Dandoy-Dron, Françoise, Itier, Jean-Michel, Monthioux, Eliane, Jami, Jacques, Joshi, Rajiv L., Bucchini, Danielle
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences of the USA 1997
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC24644/
https://ncbi.nlm.nih.gov/pubmed/9144203
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