Phenotypic alterations in insulin-deficient mutant mice

Two mouse insulin genes, Ins1 and Ins2, were disrupted and lacZ was inserted at the Ins2 locus by gene targeting. Double nullizygous insulin-deficient pups were growth-retarded. They did not show any glycosuria at birth but soon after suckling developed diabetes mellitus with ketoacidosis and liver...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Duvillié, Bertrand, Cordonnier, Nathalie, Deltour, Louise, Dandoy-Dron, Françoise, Itier, Jean-Michel, Monthioux, Eliane, Jami, Jacques, Joshi, Rajiv L., Bucchini, Danielle
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1997
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24644/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144203/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5137
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