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Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions – extending the simplified reference tissue model
AIM: The simplified reference tissue model (SRTM) is used for estimation of receptor occupancy assuming that the non-displaceable binding in the reference region is identical to the brain regions of interest. The aim of this work was to extend the SRTM to also account for inter-regional differences...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500331/ https://ncbi.nlm.nih.gov/pubmed/25406494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12558 |
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