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Accelerating Monte Carlo power studies through parametric power estimation

Estimating the power for a non-linear mixed-effects model-based analysis is challenging due to the lack of a closed form analytic expression. Often, computationally intensive Monte Carlo studies need to be employed to evaluate the power of a planned experiment. This is especially time consuming if f...

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Vydáno v:J Pharmacokinet Pharmacodyn
Hlavní autoři: Ueckert, Sebastian, Karlsson, Mats O., Hooker, Andrew C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791488/
https://ncbi.nlm.nih.gov/pubmed/26934878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-016-9468-y
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