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Pharmacokinetic interactions among imatinib, bosentan and sildenafil, and their clinical implications in severe pulmonary arterial hypertension

AIMS: This study characterized the population pharmacokinetics (PK) of imatinib in patients with severe pulmonary arterial hypertension (PAH), investigated drug–drug interactions (DDI) among imatinib, sildenafil and bosentan, and evaluated their clinical implications. METHODS: Plasma concentrations...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Renard, Didier, Bouillon, Thomas, Zhou, Ping, Flesch, Gerard, Quinn, Debbie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500327/
https://ncbi.nlm.nih.gov/pubmed/25581063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12584
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