Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

AIMS: To determine whether bosentan decreases the plasma concentration of sildenafil in patients with pulmonary arterial hypertension. METHODS: Ten patients (aged 39–77 years) with pulmonary arterial hypertension in WHO functional class III received bosentan 62.5 mg twice daily for 1 month, then 125...

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Detalhes bibliográficos
Main Authors: Paul, Gideon A, Gibbs, J Simon R, Boobis, Alan R, Abbas, Allifia, Wilkins, Martin R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884910/
https://ncbi.nlm.nih.gov/pubmed/15963102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02383.x
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